{"ambiguity":"R","ancestral_allele":"G","name":"rs699","clinical_significance":["benign","risk factor"],"minor_allele":"A","MAF":0.294928,"source":"Variants (including SNPs and indels) imported from dbSNP","synonyms":["RCV000242838","RCV000405686","RCV000019693","RCV000019691","RCV000019692","PA166153539","106150.0001","rs386606420","rs3182295","rs4714","rs61617185","rs17856353","NP_000020.1:p.Met268Thr","NM_000029.3:c.803T>C","VAR_007096"],"mappings":[{"allele_string":"A/G","location":"1:230845794-230845794","end":230845794,"coord_system":"chromosome","strand":1,"start":230845794,"assembly_name":"GRCh37","seq_region_name":"1"}],"most_severe_consequence":"missense_variant","var_class":"SNP","phenotypes":[{"source":"NHGRI-EBI GWAS catalog","ontology_accessions":["EFO:0000378","EFO:0001645","HP:0001677"],"pvalue":"2.00e-8","beta_coefficient":"0.036 unit decrease","variants":"rs699","trait":"Coronary Artery Disease","study":"PMID:29212778","risk_allele":"A","genes":"AGT"},{"trait":"HYPERTENSION, ESSENTIAL, SUSCEPTIBILITY TO","variants":null,"risk_allele":"G","genes":"AGT","ontology_accessions":["EFO:0000537","HP:0000822"],"source":"ClinVar"},{"source":"NHGRI-EBI GWAS catalog","ontology_accessions":["EFO:0006340"],"beta_coefficient":"0.32885453 unit decrease","variants":"rs699","pvalue":"4.00e-12","trait":"Mean arterial pressure","study":"PMID:27618448","genes":"AGT","risk_allele":"A"},{"ontology_accessions":["EFO:0000668","HP:0100602","Orphanet:275555"],"source":"ClinVar","trait":"Preeclampsia, susceptibility to","variants":null,"genes":"AGT","risk_allele":"G"},{"trait":"Renal dysplasia","variants":null,"genes":"AGT","risk_allele":"G","ontology_accessions":["HP:0000110","Orphanet:93108"],"source":"ClinVar"},{"variants":null,"risk_allele":"G","genes":"AGT","trait":"Susceptibility to progression to renal failure in IgA nephropathy","source":"ClinVar"}],"evidence":["Frequency","HapMap","1000Genomes","Cited","ESP","Phenotype_or_Disease","ExAC","TOPMed","gnomAD"]}