[{"name":"cytoplasmic transcription factor complex","namespace":"cellular_component","definition":"\"A protein complex, located in the cytoplasm, that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.\" [GOC:jl]","subsets":[],"ontology":"GO","accession":"GO:0044797","synonyms":[]},{"definition":"\"A protein complex, located in the nucleus, that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.\" [GOC:jl]","namespace":"cellular_component","subsets":[],"ontology":"GO","name":"nuclear transcription factor complex","synonyms":[],"accession":"GO:0044798"},{"accession":"GO:0000120","synonyms":[],"name":"RNA polymerase I transcription factor complex","namespace":"cellular_component","definition":"\"A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase I.\" [GOC:mah]","ontology":"GO","subsets":[]},{"accession":"GO:0000126","synonyms":[],"name":"transcription factor TFIIIB complex","ontology":"GO","subsets":[],"namespace":"cellular_component","definition":"\"A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIB contains the TATA-binding protein (TBP) and two Pol III-specific proteins, B'' and BRF.\" [GOC:mah, PMID:11433012]"},{"name":"transcription factor TFIIIC complex","namespace":"cellular_component","definition":"\"A heterotrimeric transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIC contains three conserved subunits that associate with the proximal Pol III promoter element, and additional subunits that associate with sequence elements downstream of the promoter and are more diverged among species. It also functions as a boundary element to partition genome content into distinct domains outside Pol III promoter regions.\" [GOC:mah, GOC:vw, PMID:11433012, PMID:16751097]","subsets":[],"ontology":"GO","accession":"GO:0000127","synonyms":[]},{"accession":"GO:0005669","synonyms":[],"name":"transcription factor TFIID complex","definition":"\"A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters.\" [GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501]","namespace":"cellular_component","ontology":"GO","subsets":[]},{"accession":"GO:0005672","synonyms":[],"name":"transcription factor TFIIA complex","ontology":"GO","subsets":[],"namespace":"cellular_component","definition":"\"A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12).\" [GOC:jl, PMID:17560669]"},{"ontology":"GO","subsets":[],"namespace":"cellular_component","definition":"\"A transcription factor which in humans consists of a complex of two alpha and two beta chains. Recruits TFIIH to the initiation complex and helps activate both RNA polymerase II and TFIIH.\" [GOC:jl, PMID:16547462]","name":"transcription factor TFIIE complex","synonyms":[],"accession":"GO:0005673"},{"subsets":[],"ontology":"GO","namespace":"cellular_component","definition":"\"A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation.\" [GOC:jl, PMID:7597077]","name":"transcription factor TFIIF complex","synonyms":[],"accession":"GO:0005674"},{"name":"holo TFIIH complex","definition":"\"A complex that contains kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. In S. cerevisiae, it is composed of the 5-subunit core (Rad3p, Tfb1p, Tfb2p, Ssl1p and Tfb4p), Ssl2p, and TFIIK (Kin28p, Ccl1p, and Tfb3p). All of the subunits have equivalents in humans: the 5 subunit core is composed of ERCC2, p62, p55, p44, p34; the equivalent of the TFIIK subcomplex is composed of MO15, Mat1, and a cyclin; the human equivalent of Ssl2p is XPB.\" [GOC:krc, PMID:14500720, PMID:7813015]","namespace":"cellular_component","ontology":"GO","subsets":[],"accession":"GO:0005675","synonyms":[]},{"synonyms":[],"accession":"GO:0008230","namespace":"cellular_component","definition":"\"A heterodimeric complex containing the products of the insect genes Ecdysone receptor (EcR) and ultraspiracle (usp). Binding of ecdysone promotes association between the two subunits, and the receptor complex then initiates molting and metamorphosis by binding DNA and regulating the transcription of target genes.\" [GOC:bf, PMID:14592980]","subsets":[],"ontology":"GO","name":"ecdysone receptor holocomplex"},{"accession":"GO:0016513","synonyms":["AML1 complex","CBF complex","PEPB2 complex"],"name":"core-binding factor complex","namespace":"cellular_component","definition":"\"A heterodimeric transcription factor complex that contains an alpha subunit (Runx1, Runx2 or Runx3 in human) that binds DNA and a non-DNA-binding beta subunit (CBFbeta), and binds to a consensus sequence 5'-YGYGGTY-3' found in several enhancers and promoters; the beta subunit enhances the DNA binding of the alpha subunit.\" [PMID:15156179, PMID:8497254]","subsets":[],"ontology":"GO"},{"subsets":[],"ontology":"GO","definition":"\"A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; in Saccharomyces it activates the transcription of genes in response to growth in a nonfermentable carbon source; consists of four known subunits: HAP2, HAP3, HAP4 and HAP5.\" [PMID:7828851]","namespace":"cellular_component","name":"CCAAT-binding factor complex","synonyms":[],"accession":"GO:0016602"},{"synonyms":["SNAPc"],"accession":"GO:0019185","subsets":[],"ontology":"GO","namespace":"cellular_component","definition":"\"A protein complex that recognizes the proximal sequence element of RNA polymerase II and III snRNA promoters.\" [PMID:7715707, PMID:9003788]","name":"snRNA-activating protein complex"},{"synonyms":["ICE activator complex"],"accession":"GO:0030232","definition":"\"Transcription factor complex that binds to the insulin control element (ICE), a DNA sequence element found within the 5'-flanking region of the insulin gene, and activates ICE-mediated transcription.\" [PMID:7935390]","namespace":"cellular_component","ontology":"GO","subsets":[],"name":"insulin control element activator complex"},{"name":"MBF transcription complex","namespace":"cellular_component","definition":"\"A protein complex that binds to the Mlu1 cell cycle box (MCB) promoter element, consensus sequence ACGCGN, and is involved in regulation of transcription during the G1/S transition of the cell cycle. In Saccharomyces, the complex contains a heterodimer of the DNA binding protein Mbp1p and the activator Swi4p, and is associated with additional proteins known as Nrm1p, Msa1p, and Msa2p; in Schizosaccharomyces the complex contains Res1p, Res2p, and Cdc10p.\" [GOC:mah, PMID:11206552, PMID:15838511, PMID:18160399, PMID:9343385]","ontology":"GO","subsets":[],"accession":"GO:0030907","synonyms":["DSC1 transcription factor complex","MBF","Mlu1-box binding factor"]},{"subsets":[],"ontology":"GO","definition":"\"A transcriptionally active complex that binds to an activin response element (ARE) in the promoter of target genes, and is composed of two SMAD2 proteins, one SMAD4 protein and a Forkhead activin signal transducer (FAST) transcription factor.\" [PMID:12374795, PMID:9288972]","namespace":"cellular_component","name":"activin responsive factor complex","synonyms":["ARF complex"],"accession":"GO:0032444"},{"synonyms":[],"accession":"GO:0033276","subsets":[],"ontology":"GO","namespace":"cellular_component","definition":"\"A protein complex that does not contain either a TATA-binding protein (TBP) or a TBP-like factor, but is composed of several TAFIIs and other proteins, including a histone acetyltransferase. This complex is able to nucleate transcription initiation by RNA polymerase II, can mediate transcriptional activation, and has histone acetyltransferase activity.\" [PMID:10373431, PMID:9603525]","name":"transcription factor TFTC complex"},{"synonyms":["SBF complex"],"accession":"GO:0033309","ontology":"GO","subsets":[],"namespace":"cellular_component","definition":"\"A protein complex that binds to the Swi4/6 cell cycle box (SCB) promoter element, consensus sequence CRCGAAA, and activates transcription during the G1/S transition of the cell cycle. In Saccharomyces, the complex contains a heterodimer of the DNA binding protein Swi6p and the activator Swi4p, and is associated with additional proteins known as Whi5p and Msa1p.\" [GOC:mah, PMID:11206552, PMID:15838511, PMID:18160399, PMID:7917338]","name":"SBF transcription complex"},{"synonyms":["TFIIIC-Topoisomerase 1-PC4 complex"],"accession":"GO:0034740","namespace":"cellular_component","definition":"\"A protein complex that contains TFIIIC, topoisomerase 1, and Sub1/PC4. Characterized in human, the complex is involved in regulating transcription from RNA polymerase III (Pol III) promoters. Topoisomerase 1 and Sub1 enhance the accuracy of transcription termination, and promote reinitiation by Pol III.\" [PMID:9660958]","ontology":"GO","subsets":[],"name":"TFIIIC-TOP1-SUB1 complex"},{"accession":"GO:0035189","synonyms":["retinoblastoma-E2F complex"],"name":"Rb-E2F complex","ontology":"GO","subsets":[],"definition":"\"A multiprotein complex containing a heterodimeric E2F transcription factor and a Retinoblastoma (Rb) family member. This complex is capable of repressing transcription of E2F-regulated genes in order to regulate cell cycle progression.\" [PMID:14616073]","namespace":"cellular_component"},{"accession":"GO:0035976","synonyms":["Activating protein 1 complex","AP-1 complex","transcription factor AP-1 complex","transcription factor AP1 complex"],"name":"AP1 complex","ontology":"GO","subsets":[],"namespace":"cellular_component","definition":"\"A heterodimeric transcription factor complex composed of proteins from the c-Fos, c-Jun, activating transcription factor (ATF) or JDP families. The subunits contain a basic leucine zipper (bZIP) domain that is essential for dimerization and DNA binding. Jun-Fos heterodimers bind preferentially to a heptamer consensus sequence (TPA responsive element (TRE)), whereas Jun-ATF dimers bind the cyclic AMP responsive element (CRE) to regulate transcription of target genes.\" [GOC:bf, GOC:BHF, GOC:rl, PMID:20060892, PMID:9069263, Wikipedia:AP-1_transcription_factor]"},{"accession":"GO:0070264","synonyms":[],"name":"transcription factor TFIIIE complex","namespace":"cellular_component","definition":"\"A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIE contains a specific subset of ribosomal proteins.\" [GOC:jp, PMID:19116144]","subsets":[],"ontology":"GO"},{"name":"SRF-myogenin-E12 complex","namespace":"cellular_component","definition":"\"A transcription factor complex that contains the serum response factor (SRF) and the basic helix-loop-helix proteins myogenin and E12, and is involved in activating transcription of muscle-specific genes.\" [PMID:8617811]","subsets":[],"ontology":"GO","accession":"GO:0070514","synonyms":[]},{"accession":"GO:0070721","synonyms":["interferon-stimulated gene factor 3 transcription complex"],"name":"ISGF3 complex","namespace":"cellular_component","definition":"\"A transcription factor complex that consists of a Stat1-Stat2 heterodimer and the IRF9 protein.\" [GOC:mah, PMID:8943351]","ontology":"GO","subsets":[]},{"accession":"GO:0071148","synonyms":[],"name":"TEAD-1-YAP complex","definition":"\"A transcription factor complex that is composed of the DNA biding protein TEAD-1 and the transcriptional coactivator YAP.\" [GOC:mah, PMID:11358867]","namespace":"cellular_component","subsets":[],"ontology":"GO"},{"subsets":[],"ontology":"GO","namespace":"cellular_component","definition":"\"A transcription factor complex that is composed of the DNA biding protein TEAD-2 and the transcriptional coactivator YAP.\" [GOC:mah, PMID:11358867]","name":"TEAD-2-YAP complex","synonyms":[],"accession":"GO:0071149"},{"synonyms":[],"accession":"GO:0071150","namespace":"cellular_component","definition":"\"A transcription factor complex that is composed of the DNA biding protein TEAD-3 and the transcriptional coactivator YAP.\" [GOC:mah, PMID:11358867]","ontology":"GO","subsets":[],"name":"TEAD-3-YAP complex"},{"synonyms":[],"accession":"GO:0071151","subsets":[],"ontology":"GO","namespace":"cellular_component","definition":"\"A transcription factor complex that is composed of the DNA biding protein TEAD-4 and the transcriptional coactivator YAP.\" [GOC:mah, PMID:11358867]","name":"TEAD-4-YAP complex"},{"ontology":"GO","subsets":[],"definition":"\"A transcription factor complex that consists of a heterodimer of the bHLH-ZIP proteins Myc and Max.\" [GOC:cna, PMID:16620027, PMID:16620031, PMID:20170194]","namespace":"cellular_component","name":"Myc-Max complex","synonyms":[],"accession":"GO:0071943"},{"accession":"GO:0097221","synonyms":["PBF complex","PBF transcription complex","PCB binding factor complex","pombe cell cycle box binding factor complex"],"name":"MADS box-forkhead transcription factor complex","subsets":[],"ontology":"GO","namespace":"cellular_component","definition":"\"A protein complex that contains a MADS-box protein and two forkhead domain proteins, and binds to and regulates transcription from promoters of genes transcribed during the M/G1 transition of the cell cycle. In Schizosaccharomyces pombe, the complex contains the MADS-box protein Mbx1 and two forkhead proteins, Sep1 and Fkh2.\" [GOC:mah, PMID:18057023]"},{"synonyms":["ModE dimer"],"accession":"GO:1990198","definition":"\"A dimeric protein complex containing two ModE subunits. Binds directly to DNA to regulate transcription, and is involved in (positively and negatively) regulating various aspects of molybdenum metabolism.\" [GOC:bhm, PMID:12581638]","namespace":"cellular_component","ontology":"GO","subsets":[],"name":"ModE complex"},{"name":"SSL2-core TFIIH complex portion of holo TFIIH complex","subsets":[],"ontology":"GO","definition":"\"The SSL2-core TFIIH complex when it is part of the general transcription factor TFIIH. It is composed of the tightly associated five subunit core TFIIH subcomplex plus one additional, less tighly associated subunit. The subunits are well conserved from yeast to humans. In S. cerevisiae, the 5-subunit core is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4 and the loosely associated subunit is Ssl2p (also called Rad25). In humans, the 5 subunit core is composed of ERCC2, p62, p55, p44, p34 and the loosely associated subunit is XPB.\" [GOC:krc, PMID:14500720, PMID:7813015]","namespace":"cellular_component","accession":"GO:0000443","synonyms":[]},{"accession":"GO:0000500","synonyms":["RNA polymerase I upstream activation factor complex","UAF"],"name":"RNA polymerase I upstream activating factor complex","definition":"\"A complex required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrrn5p, Rrn9p, Rrn10p, histones H3 and H4, and Uaf30p.\" [PMID:11500378]","namespace":"cellular_component","subsets":[],"ontology":"GO"},{"accession":"GO:0005668","synonyms":["selectivity factor SL1 complex","TIF-IB"],"name":"RNA polymerase transcription factor SL1 complex","namespace":"cellular_component","definition":"\"A RNA polymerase I-specific transcription factor complex that contains the TATA-box-binding protein (TBP) and at least three TBP-associated factors including proteins known in mammals as TAFI110, TAFI63 and TAFI48.\" [PMID:15691654]","ontology":"GO","subsets":[]},{"accession":"GO:0008231","synonyms":["repressor ecdysone receptor holocomplex"],"name":"repressor ecdysone receptor complex","ontology":"GO","subsets":[],"namespace":"cellular_component","definition":"\"A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) plus an associated corepressor such as SMRTER, which represses transcription of target genes.\" [PMID:10488333]"},{"accession":"GO:0008232","synonyms":["activator ecdysone receptor holocomplex"],"name":"activator ecdysone receptor complex","namespace":"cellular_component","definition":"\"A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) bound to the ligand ecdysone, which activates transcription of target genes.\" [PMID:10488333]","subsets":[],"ontology":"GO"},{"name":"transcription factor TFIIIB-alpha complex","definition":"\"A transcription factor TFIIIB-beta complex that contains the TATA-binding protein (TBP), B'' and a specialized homolog of the conserved subunit BRF referred to as BRFU or TFIIIB50, which found in human but not conserved in yeast; the complex is involved in the regulation of transcription from type 3 (upstream) RNA polymerase III promoters.\" [PMID:11433012]","namespace":"cellular_component","ontology":"GO","subsets":[],"accession":"GO:0034732","synonyms":[]},{"accession":"GO:0034733","synonyms":[],"name":"transcription factor TFIIIB-beta complex","ontology":"GO","subsets":[],"namespace":"cellular_component","definition":"\"A transcription factor TFIIIB-beta complex that contains the TATA-binding protein (TBP), B'' and BRF, and is involved in the regulation of transcription from type 2 RNA polymerase III promoters.\" [PMID:11433012]"},{"name":"transcription factor TFIIIC1 complex","ontology":"GO","subsets":[],"definition":"\"A transcription factor complex that forms part of the TFIIIC complex, observed in human. The complex is poorly characterized, but contains the 250-kDa form of HsBdp1, and is thought to include nuclear factor 1 (NF1). It stimulates binding by human TFIIIC2 and is required for transcription activity.\" [GOC:mah, PMID:11433012, PMID:15096501]","namespace":"cellular_component","accession":"GO:0034734","synonyms":[]},{"name":"transcription factor TFIIIC2 complex","namespace":"cellular_component","definition":"\"A transcription factor complex that forms part of the TFIIIC complex, observed in human; composed of five subunits (GTF3C1/hTFIIIC220/TFIIICalpha, GTF3C2/hTFIIIC110/TFIIICbeta, GTF3C3/hTFIIIC102/TFIIICgamma, GTF3C4/hTFIIIC90/TFIIICdelta and GTF3C5/hTFIIIC63/TFIIICepsilon in human) that together recognize the type 2 RNA polymerase III promoter.\" [GOC:mah, PMID:11433012]","ontology":"GO","subsets":[],"accession":"GO:0034735","synonyms":[]},{"accession":"GO:0070556","synonyms":["TFIID complex, B-cell specific"],"name":"TAF4B-containing transcription factor TFIID complex","definition":"\"A transcription factor TFIID complex that contains the TBP-associated factor TAF4B (also known as TAFII105 in human), a cell-type-specific variant of TAF4.\" [GOC:mah, PMID:8858156]","namespace":"cellular_component","ontology":"GO","subsets":[]},{"name":"RNA polymerase I core factor complex","ontology":"GO","subsets":[],"namespace":"cellular_component","definition":"\"A RNA polymerase I-specific transcription factor complex that is required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrn6p, Rrn7p, and Rrn11p.\" [PMID:8702872]","accession":"GO:0070860","synonyms":[]},{"accession":"GO:0070985","synonyms":[],"name":"TFIIK complex","namespace":"cellular_component","definition":"\"A transcription factor complex that forms part of the holo TFIIH complex. In Saccharomyces, TFIIK contains Ccl1p, Tfb3p and Kin2p.\" [GOC:mah, PMID:19818408]","subsets":[],"ontology":"GO"},{"accession":"GO:1990243","synonyms":[],"name":"atf1-pcr1 complex","namespace":"cellular_component","definition":"\"A heterodimeric transcription factor complex composed of the bZIP proteins atf1 and pcr1. The heterodimer binds m26 sites (homologous to CRE).\" [PMID:24224056]","ontology":"GO","subsets":[]},{"name":"core TFIIH complex portion of holo TFIIH complex","namespace":"cellular_component","definition":"\"The core TFIIH complex when it is part of the general transcription factor TFIIH. In S. cerevisiae, it is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p and Tfb4p. In humans, it is composed of ERCC2, p62, p55, p44, p34.\" [GOC:krc, PMID:14500720, PMID:7813015]","ontology":"GO","subsets":[],"accession":"GO:0000438","synonyms":[]}]